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Call of the wild: antibiotic resistance genes in natural environments
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Abstract
Antibiotic-resistant pathogens are profoundly important to human health, but the environmental
reservoirs of resistance determinants are poorly understood. The origins of antibiotic
resistance in the environment is relevant to human health because of the increasing
importance of zoonotic diseases as well as the need for predicting emerging resistant
pathogens. This Review explores the presence and spread of antibiotic resistance in
non-agricultural, non-clinical environments and demonstrates the need for more intensive
investigation on this subject.