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      Effects of Estrogen, Pituitary Gonadotropins and Prolactin on Immunohistochemical Localization of Inhibin Subunits in the Ovary of Hypophysectomized Female Rats

      , , ,

      Hormone Research in Paediatrics

      S. Karger AG

      Immunohistochemistry, Ovary, Inhibin, Female rat

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          Abstract

          Effects of estrogen, pituitary gonadotropins and prolactin on immunohistochemical localization of α- and β<sub>A</sub>-subunits in the ovaries of hypophysectomized female rats were investigated. Hypophysectomy resulted in disappearance of immunoreactive inhibin subunits in the ovary. Administration of DES, FSH and LH to hypophysectomized rats provoked growth of follicles, and resulted in positive immunostaining for inhibin subunits in the granulosa cells. In contrast to follicle-stimulating hormone (FSH) and luteinizing hormone (LH), prolactin administration failed to demonstrate positive staining for inhibin subunits in the ovary. The present in vivo results suggest that several hormones which are known to stimulate granulosa cell growth and maturation, such as estrogen, FSH and LH, enhance inhibin subunit production by the overy. The morphologic aspect of inhibin subunit production by the ovary in response to several hormones has been demonstrated in the present study.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1992
          1992
          03 December 2008
          : 37
          : 3
          : 107-112
          Affiliations
          Department of Obstetrics and Gynecology, Wakayama Medical College, Wakayama, Japan
          Article
          182292 Horm Res 1992;37:107–112
          10.1159/000182292
          1478625
          © 1992 S. Karger AG, Basel

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          Page count
          Pages: 6
          Categories
          Original Paper

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