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      Design and fabrication of multi-functional targeted photosensitizer-chemo drug-encapsulated perfluorocarbon nanodroplets for cancer treatment

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      Science Impact, Ltd.

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          Abstract

          The innovative research described in this article is based on perfluorocarbon (PFC) nanodroplets. PFCs are organofluorine compounds that contain only carbon and fluorine and, in this research, they are the blank nanoparticle in a double-layer emulsion format (water-in-PFC-in-water) without any surface modification nor entrapped material. ‘More specifically, PFC nanodroplets consist of three layers: a carboxylic poly (ethylene oxide)-block-poly(propylene oxide)-block-poly(ethy1ene oxide) (i.e., PEO-PPO-PEO block copolymer) as the outer layer material; a polyethoxylated fluorosurfactant as the inner layer material; and a perfluorooctyl bromide (PFOB) as the PFC material located between these two layers,’ explains Lee. ‘Tumour-target photosensitizer-anticancer drug-encapsulated PFC nanodroplet with double emulsion format is an ideal, effective, and clinically applicable drug carrier,’ he says. ‘The polymers used for both inner and outer layers are biocompatible, and the PFOB, a fluorine-substituted derivative of hydrocarbons, is a well-known robust oxygen transporter that is widely used as a contrast agent in MRI, CT and sonography applications.

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          Author and article information

          Journal
          Impact
          impact
          Science Impact, Ltd.
          2398-7073
          December 31 2018
          December 31 2018
          : 2018
          : 12
          : 79-81
          Article
          10.21820/23987073.2018.12.79
          © 2018

          This work is licensed under a Creative Commons Attribution 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

          Earth & Environmental sciences, Medicine, Computer science, Agriculture, Engineering

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