Cardiac Changes from Beta-Blocker, Diuretic and Minoxidil Combination in Hypertension

Abstract

The open, long-term antihypertensive, hemodynamic and metabolic effects of betaxolol in combination with furosemide and minoxidil were investigated on 30 male patients with moderate to severe essential hypertension. Twenty-three patients were observed for 104 weeks, and 7 patients for 128 weeks. The patients were seen in the clinic every 4 weeks. Blood chemistries, electrocardiograms, chest x-rays and echocardiograms were done at set intervals during the study. This drug combination caused a significant and sustained decrease in arterial pressure and heart rate (p < 0.001), a significant increase in the cardiothoracic ratio (p < 0.05), left and right ventricular diameter in end diastole and in left ventricular mass (p < 0.001), and had no effect on left ventricular wall thickness, interventricular septal thickness, left ventricular ejection fraction, myocardial fiber shortening or metabolic functions. Clinical side effects included hypertrichosis, weight gain and edema. We conclude: (1) Single daily administration of betaxolol, furosemide and minoxidil produced a significant and sustained antihypertensive effect. (2) It caused cardiac enlargement and increased left ventricular mass without deterioration of myocardial function. (3) The clinical significance of the latter findings is not known at present time.

Journal

Journal ID (publisher-id): CRD

Journal ID (nlm-ta): Cardiology

Journal ID (doi): 10.1159/issn.0008-6312

Title: Cardiology

Publisher: S. Karger AG

ISSN (Print): 0008-6312

ISSN (Electronic): 1421-9751

Publication date Subscription-year: 1991

Publication date (Print): 1991

Publication date (Electronic): 12 November 2008

Volume: 78

Issue: 1

Pages: 45-52

Affiliations

^aOklahoma Cardiovascular and Hypertension Center; ^bUniversity of Oklahoma, Oklahoma City, Okla., USA

Article

Publisher ID: 174764 Other ID: Cardiology 1991;78:45–52

DOI: 10.1159/000174764

PubMed ID: 1827043

Copyright statement: © 1991 S. Karger AG, Basel

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Page count

Pages: 8

Product

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Categories

Subject: Original Paper