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      Glycosaminoglycan Distribution in Atherosclerotic Saphenous Vein Grafts

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          Abstract

          Glycosaminoglycan composition of normal saphenous veins and atherosclerotic saphenous vein grafts is reported. Dermatan sulfate is the main glycosaminoglycan present in both normal saphenous veins and saphenous vein grafts. These tissues also contain chondroitin sulfate and heparan sulfate. Although the total amount of glycosaminoglycans decreased in the grafts (compared with normal saphenous veins), the grafts showed an increase in the relative amounts of dermatan sulfate and chondroitin sulfate. Heparan sulfate was decreased, compared with normal controls. These findings suggest the involvement of blood vessel glycosaminoglycans (not only the arterial glycosaminoglycans) in the process of atherosclerosis.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1995
          1995
          18 November 2008
          : 86
          : 2
          : 143-146
          Affiliations
          aPró-Sangue Foundation Hemocentro de São Paulo, bClinical Laboratory and cSurgical Division of the Heart Institute, University of São Paulo School of Medicine, dDepartment of Morphology, Escola Paulista de Medicina, São Paulo, Brazil
          Article
          176860 Cardiology 1995;86:143–146
          10.1159/000176860
          7728804
          © 1995 S. Karger AG, Basel

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          Page count
          Pages: 4
          Categories
          Cardiac Surgery

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