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      Relation of Race, Age, and Sex Hormone Differences to Serum Leptin Concentrations in Children and Adolescents

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          We explored the effects of race, age, and sex hormones on the serum leptin concentrations in 203 white and 88 black children and adolescents (ages 9.3–20.5 years). A significant sex by race interaction on serum leptin levels (p = 0.0301) was observed with lower serum leptin concentrations, adjusted for subscapular thickness and age, in black boys than in white boys. Girls had serum leptin levels that were on average 2.15 times those of boys (p < 0.0001). There was an age by sex interaction (p < 0.0001) with serum leptin concentrations decreasing in boys but not in girls with age. A strongly inverse relationship of serum testosterone levels with serum leptin levels in boys (p = 0.0067) appeared to explain this effect of age. In conclusion, the serum leptin concentration is slightly lower in black boys. A higher testosterone level in boys appears to account for an age-related decline in serum leptin in boys and the overall lower levels in boys than in girls.

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          Most cited references 5

          • Record: found
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          Identification and expression cloning of a leptin receptor, OB-R.

          The ob gene product, leptin, is an important circulating signal for the regulation of body weight. To identify high affinity leptin-binding sites, we generated a series of leptin-alkaline phosphatase (AP) fusion proteins as well as [125I]leptin. After a binding survey of cell lines and tissues, we identified leptin-binding sites in the mouse choroid plexus. A cDNA expression library was prepared from mouse choroid plexus and screened with a leptin-AP fusion protein to identify a leptin receptor (OB-R). OB-R is a single membrane-spanning receptor most related to the gp130 signal-transducing component of the IL-6 receptor, the G-CSF receptor, and the LIF receptor. OB-R mRNA is expressed not only in choroid plexus, but also in several other tissues, including hypothalamus. Genetic mapping of the gene encoding OB-R shows that it is within the 5.1 cM interval of mouse chromosome 4 that contains the db locus.
            • Record: found
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            Effects of gender, body composition, and menopause on plasma concentrations of leptin

             M. Rosenbaum (1996)
              • Record: found
              • Abstract: not found
              • Article: not found

              Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates

               R E Ostlund (1996)

                Author and article information

                Horm Res Paediatr
                Hormone Research in Paediatrics
                S. Karger AG
                May 1998
                03 April 1998
                : 49
                : 5
                : 240-246
                a Department of Medicine, Indiana University School of Medicine, and the VA Medical Center Indianapolis, Ind., and b Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, Ind., USA
                23178 Horm Res 1998;49:240–246
                © 1998 S. Karger AG, Basel

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                Page count
                Figures: 5, Tables: 3, References: 19, Pages: 7
                Original Paper


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