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      21-Deoxytetrahydroaldosterone Excretion in Primary Hyperaldosteronism

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          Abstract

          In earlier studies by our group it was shown that the urinary tetrahydroaldosterone excretion is a more reliable test for the diagnosis of primary aldosteronism than aldosterone-18-glucuronide (‘urinary aldosterone’). However, in several patients with primary aldosteronism even the tetrahydroaldosterone values remained in the normal range. As the possible cause for this observation, the role of intestinal bacteria was considered which may transform tetrahydroaldosterone into 21-deoxytetrahydroaldosterone. Using a 21-deoxytetrahydroaldosterone radioimmunoassay, this hypothesis could be confirmed. The sums of the urinary 21-deoxytetrahydroaldosterone and tetahydroaldosterone excretions revealed to be of better diagnostic value than the tetrahydroaldosterone values alone.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          978-3-8055-4079-7
          978-3-318-00139-6
          0008-6312
          1421-9751
          1985
          1985
          11 November 2008
          : 72
          : Suppl 1
          : 102-106
          Affiliations
          aNephrology and Hypertension Unit, Deutsche Klinik für Diagnostik, Wiesbaden; bDepartment of Pharmacology, University of Heidelberg, FRG; cDepartment of Pathology, St. Luke’s-Roosevelt Hospital Center, New York, N.Y., USA
          Article
          173954 Cardiology 1985;72:102–106
          10.1159/000173954
          4053120
          © 1985 S. Karger AG, Basel

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          Pages: 5
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