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      Increased Circulating Interleukin-1 and Interleukin-6 after Intracerebroventricular Injection of Lipopolysaccharide

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          Recently, it was demonstrated that intracerebroventricular (icv) injection of interleukin-1 (IL-1) stimulated circulating interleukin-6 (IL-6) to a greater degree than intravenous (iv) injection of IL-1. The goal of this study was to compare the efficacy of lipopolysaccharide (LPS), injected both icv and iv, on circulating concentrations of IL-1 and IL-6. Both iv and icv injection of LPS stimulated plasma levels of IL-1 to a similar degree. However, iv injection of LPS was significantly more efficacious than icv injection of LPS in elevating circulating IL-6. These results demonstrate that like iv injection of LPS, icv injection of LPS stimulates plasma levels of IL-1 and IL-6. Increases in circulating cytokines during infectious diseases which are limited to the central nervous system may serve to activate peripheral functions of an acute phase response.

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          Author and article information

          S. Karger AG
          07 April 2008
          : 56
          : 6
          : 935-938
          US-Japan Biomedical Research Laboratories, Tulane University, Hebert Center, Belle Chasse, La.; Departments of Medicine, Anatomy and Physiology, Tulane University School of Medicine, New Orleans, La., USA
          126328 Neuroendocrinology 1992;56:935–938
          © 1992 S. Karger AG, Basel

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