Increased Circulating Interleukin-1 and Interleukin-6 after Intracerebroventricular Injection of Lipopolysaccharide

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Abstract

Recently, it was demonstrated that intracerebroventricular (icv) injection of interleukin-1 (IL-1) stimulated circulating interleukin-6 (IL-6) to a greater degree than intravenous (iv) injection of IL-1. The goal of this study was to compare the efficacy of lipopolysaccharide (LPS), injected both icv and iv, on circulating concentrations of IL-1 and IL-6. Both iv and icv injection of LPS stimulated plasma levels of IL-1 to a similar degree. However, iv injection of LPS was significantly more efficacious than icv injection of LPS in elevating circulating IL-6. These results demonstrate that like iv injection of LPS, icv injection of LPS stimulates plasma levels of IL-1 and IL-6. Increases in circulating cytokines during infectious diseases which are limited to the central nervous system may serve to activate peripheral functions of an acute phase response.

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Author and article information

Journal

Journal ID (publisher-id): NEN

Journal ID (nlm-ta): Neuroendocrinology

Journal ID (doi): 10.1159/issn.0028-3835

Title: Neuroendocrinology

Publisher: S. Karger AG

ISSN (Print): 0028-3835

ISSN (Electronic): 1423-0194

Publication date Subscription-year: 1992

Publication date (Print): 1992

Publication date (Electronic): 07 April 2008

Volume: 56

Issue: 6

Pages: 935-938

Affiliations

US-Japan Biomedical Research Laboratories, Tulane University, Hebert Center, Belle Chasse, La.; Departments of Medicine, Anatomy and Physiology, Tulane University School of Medicine, New Orleans, La., USA

Article

Publisher ID: 126328 Other ID: Neuroendocrinology 1992;56:935–938

DOI: 10.1159/000126328

PubMed ID: 1369606

SO-VID: 84a7d016-5540-4594-9ea1-b1a709c19d0b

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 09 July 1992

Date accepted : 23 September 1992

Page count

Pages: 4

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