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      Radiotherapy enhancement with gold nanoparticles.

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          Abstract

          Gold is an excellent absorber of X-rays. If tumours could be loaded with gold, this would lead to a higher dose to the cancerous tissue compared with the dose received by normal tissue during a radiotherapy treatment. Calculations indicate that this dose enhancement can be significant, even 200% or greater. In this paper, the physical and biological parameters affecting this enhancement are discussed. Gold nanoparticles have shown therapeutic efficacy in animal trials and these results are reviewed. Some 86% long-term (>1 year) cures of EMT-6 mouse mammary subcutaneous tumours was achieved with an intravenous injection of gold nanoparticles before irradiation with 250-kVp photons, whereas only 20% were cured with radiation alone. The clinical potential of this approach is also discussed.

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          Author and article information

          Journal
          J Pharm Pharmacol
          The Journal of pharmacy and pharmacology
          Royal Pharmaceutical Society
          0022-3573
          0022-3573
          Aug 2008
          : 60
          : 8
          Affiliations
          [1 ] Nanoprobes, Inc., 95 Horseblock Road, Yaphank, NY 11980-9710, USA. hainfeld@nanoprobes.com
          Article
          10.1211/jpp.60.8.0005
          18644191
          84abc431-7f15-4d6d-8db7-f0d29aeb8aa1
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