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      Bioanalytical HPLC Applications of In-Tube Solid Phase Microextraction: A Two-Decade Overview

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          Abstract

          In-tube solid phase microextraction is a cutting-edge sample treatment technique offering significant advantages in terms of miniaturization, green character, automation, and preconcentration prior to analysis. During the past years, there has been a considerable increase in the reported publications, as well as in the research groups focusing their activities on this technique. In the present review article, HPLC bioanalytical applications of in-tube SPME are discussed, covering a wide time frame of twenty years of research reports. Instrumental aspects towards the coupling of in-tube SPME and HPLC are also discussed, and detailed information on materials/coatings and applications in biological samples are provided.

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          Diagnostic potential of breath analysis--focus on volatile organic compounds.

          Wolfram Miekisch, Jochen K. Schubert, Gabriele Noeldge-Schomburg (2004)
          Breath analysis has attracted a considerable amount of scientific and clinical interest during the last decade. In contrast to NO, which is predominantly generated in the bronchial system, volatile organic compounds (VOCs) are mainly blood borne and therefore enable monitoring of different processes in the body. Exhaled ethane and pentane concentrations were elevated in inflammatory diseases. Acetone was linked to dextrose metabolism and lipolysis. Exhaled isoprene concentrations showed correlations with cholesterol biosynthesis. Exhaled levels of sulphur-containing compounds were elevated in liver failure and allograft rejection. Looking at a set of volatile markers may enable recognition and diagnosis of complex diseases such as lung or breast cancer. Due to technical problems of sampling and analysis and a lack of normalization and standardization, huge variations exist between results of different studies. This is among the main reasons why breath analysis could not yet been introduced into clinical practice. This review addresses the basic principles of breath analysis and the diagnostic potential of different volatile breath markers. Analytical procedures, issues concerning biochemistry and exhalation mechanisms of volatile substances, and future developments will be discussed.
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            Advances in Solid Phase Microextraction and Perspective on Future Directions

            Emanuela Gionfriddo, Nathaly Reyes-Garcés, Barbara Bojko … (2017)
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              Recent Applications of Ionic Liquids in Separation Technology

              Dandan Han, Kyung Row (2010)
              Ionic liquids (ILs) have been applied in different areas of separation, such as ionic liquid supported membranes, as mobile phase additives and surface-bonded stationary phases in chromatography separations and as the extraction solvent in sample preparations, because they can be composed from various cations and anions that change the properties and phase behavior of liquids. Although the applications of ILs in separations are still in their early stages, the academic interest in ILs is increasing. An overview of the principle applications of ILs in separation technology is present in this work. Furthermore, the prospects of the ILs in separation techniques are discussed.
              Article 0 comments Cited 72 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Francisco Pena-Pereira: Role: Academic Editor
                Journal
                Journal ID (nlm-ta): Molecules
                Journal ID (iso-abbrev): Molecules
                Journal ID (publisher-id): molecules
                Title: Molecules
                Publisher: MDPI
                ISSN (Electronic): 1420-3049
                Publication date (Electronic): 30 April 2020
                Publication date Collection: May 2020
                Volume: 25
                Issue: 9
                Electronic Location Identifier: 2096
                Affiliations
                [1 ]Laboratory of Analytical Chemistry, School of Chemistry, Faculty of Sciences, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece; nmanousi@ 123456chem.auth.gr (N.M.); ptzanava@ 123456chem.auth.gr (P.D.T.)
                [2 ]Laboratory of Pharmaceutical Analysis, Department of Pharmaceutical Technology, School of Pharmacy, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece
                Author notes
                [* ]Correspondence: czacharis@ 123456pharm.auth.gr ; Tel.: +30-231-099-7663
                Author information
                https://orcid.org/0000-0002-1516-8012
                https://orcid.org/0000-0002-2366-6038
                https://orcid.org/0000-0001-9362-8523
                Article
                Publisher ID: molecules-25-02096
                DOI: 10.3390/molecules25092096
                PMC ID: 7248733
                PubMed ID: 32365828
                SO-VID: 84b133f9-74ae-4e04-97f2-72246187261a
                Copyright © © 2020 by the authors.
                License:

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 14 April 2020
                Date accepted : 29 April 2020
                Categories
                Subject: Review

                Keywords: bioanalysis,in-tube,solid phase microextraction,separation,sample preparation,review
                Data availability:
                Keywords: bioanalysis, in-tube, solid phase microextraction, separation, sample preparation, review

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