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      Cognitive Performance in Subjects With Multiple Sclerosis Is Robustly Influenced by Gender in Canonical-Correlation Analysis.

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          Abstract

          The authors explored the relations between clinical/demographic characteristics and performance on a neuropsychological battery (eight tests) in a cohort (N=46) of multiple sclerosis (MS) subjects. Findings resulted from a secondary analysis of a study examining the relationships between imaging biomarkers in MS and cognitive tasks of executive functioning. The objective was to determine whether the overlapping test results could be judiciously combined and associated with clinical/demographic variables. Canonical-correlation analysis (CCA) was utilized, and it was found that differences between performance on untimed tests, and the sum of performance on timed Trail-Making Tests, Parts A and B, best matched clinical/demographic variables, and gender was the most important feature.

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          Author and article information

          Journal
          J Neuropsychiatry Clin Neurosci
          The Journal of neuropsychiatry and clinical neurosciences
          American Psychiatric Publishing
          1545-7222
          0895-0172
          2017
          : 29
          : 2
          Affiliations
          [1 ] From the Graduate Program in Neuroscience, University of British Columbia (S-JL, MM); the Department of Statistics, University of British Columbia (JL); the Graduate Program in Counselling Psychology, University of British Columbia (SB); the Department of Radiology, University of British Columbia (IV, AM); the Department of Neurology, Faculty of Medicine, University of British Columbia (AT, DL, MM); the Department of Physics and Astronomy, University of British Columbia (AM); and the Department of Psychiatry, University of British Columbia Hospital (BK).
          Article
          10.1176/appi.neuropsych.16040083
          27899053
          84b66040-47e6-4e76-bd53-cb8df00e8342
          History

          Multiple Sclerosis,Neuropsychology
          Multiple Sclerosis, Neuropsychology

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