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Neural correlates of improved executive function following erythropoietin treatment in mood disorders.
K W Miskowiak
1 ,
M Vinberg
1 ,
L Glerup
1 ,
O B Paulson
2 ,
G M Knudsen
3 ,
H Ehrenreich
4 ,
C J Harmer
5 ,
L V Kessing
1 ,
H R Siebner
2 ,
J Macoveanu
1
June 2016
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Abstract
Cognitive dysfunction in depression and bipolar disorder (BD) is insufficiently targeted by available treatments. Erythropoietin (EPO) increases neuroplasticity and may improve cognition in mood disorders, but the neuronal mechanisms of these effects are unknown. This functional magnetic resonance imaging (fMRI) study investigated the effects of EPO on neural circuitry activity during working memory (WM) performance.