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      Microglia as neuroprotective, immunocompetent cells of the CNS.

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      Glia
      Wiley

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          Abstract

          The role of glial cells is to support and sustain proper neuronal function and microglia are no exception to this. This viewpoint article emphasizes the fundamental interdependence of microglia and neurons and takes a look at the possibility of what could happen if microglial cells became dysfunctional as a result of aging, genetics, or epigenetics. Could microglial senescence be a factor in the pathogenesis of Alzheimer's and other neurodegenerative diseases? The cautious answer to that question is 'yes'. Future studies along these lines may provide novel insights into microglial involvement in neurodegenerative disease pathogenesis.

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          Author and article information

          Journal
          Glia
          Glia
          Wiley
          0894-1491
          0894-1491
          Nov 2002
          : 40
          : 2
          Affiliations
          [1 ] Department of Neuroscience, University of Florida College of Medicine and McKnight Brain Institute, Gainesville, Florida 32611, USA. streit@mbi.ufl.edu
          Article
          10.1002/glia.10154
          12379901
          84bf6d4d-19a4-42d5-956d-7f760d2d8d84
          Copyright 2002 Wiley-Liss, Inc.
          History

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