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      The pathogenesis of murine coronavirus infection of the central nervous system.

      Critical reviews in immunology
      Animals, Central Nervous System Viral Diseases, immunology, pathology, virology, Coronavirus Infections, Host-Pathogen Interactions, Humans, Multiple Sclerosis, Murine hepatitis virus, pathogenicity

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          Abstract

          Mouse hepatitis virus (MHV) is a positive-strand RNA virus that causes an acute encephalomyelitis that later resolves into a chronic fulminating demyelinating disease. Cytokine production, chemokine secretion, and immune cell infiltration into the central nervous system are critical to control viral replication during acute infection. Despite potent antiviral T-lymphocyte activity, sterile immunity is not achieved, and MHV chronically persists within oligodendrocytes. Continued infiltration and activation of the immune system, a result of the lingering viral antigen and RNA within oligodendrocytes, lead directly to the development of an immune-mediated demyelination that bears remarkable similarities, both clinically and histologically, to the human demyelinating disease multiple sclerosis. MHV offers a unique model system for studying host defense during acute viral infection and immune-mediated demyelination during chronic infection.

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          Author and article information

          Journal
          20370625
          2852265
          10.1615/critrevimmunol.v30.i2.20

          Chemistry
          Animals,Central Nervous System Viral Diseases,immunology,pathology,virology,Coronavirus Infections,Host-Pathogen Interactions,Humans,Multiple Sclerosis,Murine hepatitis virus,pathogenicity

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