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Biomimetic calcium phosphate coatings as bone morphogenetic protein delivery systems in spinal fusion
Author(s):
Kamran Majid
,
Michael D. Tseng
,
Kevin C. Baker
,
Alma Reyes-Trocchia
,
Harry N. Herkowitz
Publication date
Created:
June 2011
Publication date
(Print):
June 2011
Journal:
The Spine Journal
Publisher:
Elsevier BV
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Abstract
Use of recombinant human bone morphogenetic protein-2 (rhBMP-2) has been shown to enhance spinal fusion rates. Case reports of soft-tissue swelling, ectopic bone formation, and osteolysis have recently surfaced. It is hypothesized that incorporation of rhBMP-2 within a calcium phosphate (CaP) coating may help to localize delivery and mitigate these complications. To compare the characteristics of posterolateral fusion between rabbits receiving rhBMP-2 delivered via physical adsorption to a collagen sponge or rhBMP-2 incorporated within the physical structure of a CaP coating on a collagen sponge. New Zealand white rabbit model of posterolateral lumbar fusion at L5-L6. Eighteen (18) New Zealand white rabbits underwent posterolateral spinal fusion at L5-L6. Rabbits received bilateral collagen sponges that were either coated with CaP (n=3), coated with CaP and dipped in rhBMP-2 (n=3), coated with a hybrid CaP-rhBMP-2 film (n=6), or coated with a hybrid CaP-rhBMP-2 film and dipped in rhBMP-2 (n=6). Animals were followed weekly with radiographs and were sacrificed at 6 weeks. Fusion masses were further characterized by manual palpation, computed tomography, and histology. Radiographic evaluation showed that animals in Group 3 (incorporated BMP) fused at 4 weeks, whereas animals in Group 2 (adsorbed BMP) and Group 4 (incorporated and adsorbed BMP) fused by 6 weeks. Animals that received rhBMP-2 physically adsorbed to the collagen sponge showed extension of the fusion mass beyond the L5-L6 level in 56% of cases and bone resorption in 78%. Histology of fusion masses showed mature bone formation in animals belonging to Groups 2, 3, and 4 and extensive osteoclast recruitment in animals belonging to Groups 2 and 4. Delivery of rhBMP-2 via incorporation within CaP coatings results in increased rates of radiographic fusion. The burst release profile of rhBMP-2 adsorbed to surfaces, although effective in achieving fusion, may result in increased osteoclast recruitment. Copyright © 2011 Elsevier Inc. All rights reserved.
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RNA drug delivery
Author and article information
Journal
Title:
The Spine Journal
Abbreviated Title:
The Spine Journal
Publisher:
Elsevier BV
ISSN (Print):
15299430
Publication date Created:
June 2011
Publication date (Print):
June 2011
Volume
: 11
Issue
: 6
Pages
: 560-567
Article
DOI:
10.1016/j.spinee.2009.12.006
PubMed ID:
20097616
SO-VID:
84bfc469-5773-470a-8198-42c1bd56f059
Copyright ©
© 2011
License:
https://www.elsevier.com/tdm/userlicense/1.0/
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