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      Are personnel with a past history of mental disorders disproportionately vulnerable to the effects of deployment-related trauma? A cross-sectional study of Canadian military personnel

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          Abstract

          Background

          Past mental disorders predict future disorders, both in the presence and absence of trauma exposure. However, it is not clear whether those with past mental disorders are disproportionately vulnerable to the negative effects of a given level of trauma.

          Methods

          The data source was the 2013 Canadian Forces Mental Health Survey (CFMHS), of which 1820 respondents had deployed only once in their military careers—all in support of the mission in Afghanistan. The primary outcomes were past 12-month depression and past 12-month PTSD. Multivariate logistic regression was performed for each outcome variable, looking primarily for differences in the marginal effect of deployment-related trauma in those with and without a pre-deployment history of each disorder.

          Results

          A history of each pre-deployment disorder did indeed interact with deployment-related trauma with respect to the corresponding past 12-month disorder. In addition, pre-deployment history of depression and of PTSD interacted with each other, though only for the outcome of past 12-month PTSD. The average marginal effect of deployment-related trauma on past 12-month PTSD was highest in those with a pre-deployment history of depression in the absence of a pre-deployment history of PTSD. This group was twice as vulnerable to post-deployment PTSD relative to those without a pre-deployment history of both disorders and four times as vulnerable to post-deployment PTSD relative to those with a pre-deployment history of both disorders. No significant differences were seen in the marginal effects of trauma on past 12-month depression in the presence or absence of a pre-deployment history of that disorder.

          Conclusion

          There is modest differential vulnerability to past 12-month PTSD as a function of deployment-related trauma in those who had a pre-deployment history of PTSD or depression when compared to those who did and did not have a pre-deployment history of one or both disorders.

          Electronic supplementary material

          The online version of this article (10.1186/s12888-019-2146-z) contains supplementary material, which is available to authorized users.

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          Most cited references36

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          Dominance analysis: A new approach to the problem of relative importance of predictors in multiple regression.

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            Concordance of the Composite International Diagnostic Interview Version 3.0 (CIDI 3.0) with standardized clinical assessments in the WHO World Mental Health Surveys

            The DSM‐IV diagnoses generated by the fully structured lay‐administered Composite International Diagnostic Interview Version 3.0 (CIDI 3.0) in the WHO World Mental Health (WMH) surveys were compared to diagnoses based on follow‐up interviews with the clinician‐administered non‐patient edition of the Structured Clinical Interview for DSM‐IV (SCID) in probability subsamples of the WMH surveys in France, Italy, Spain, and the US. CIDI cases were oversampled. The clinical reappraisal samples were weighted to adjust for this oversampling. Separate samples were assessed for lifetime and 12‐month prevalence. Moderate to good individual‐level CIDI‐SCID concordance was found for lifetime prevalence estimates of most disorders. The area under the ROC curve (AUC, a measure of classification accuracy that is not influenced by disorder prevalence) was 0.76 for the dichotomous classification of having any of the lifetime DSM‐IV anxiety, mood and substance disorders assessed in the surveys and in the range 0.62–0.93 for individual disorders, with an inter‐quartile range (IQR) of 0.71–0.86. Concordance increased when CIDI symptom‐level data were added to predict SCID diagnoses in logistic regression equations. AUC for individual disorders in these equations was in the range 0.74–0.99, with an IQR of 0.87–0.96. CIDI lifetime prevalence estimates were generally conservative relative to SCID estimates. CIDI‐SCID concordance for 12‐month prevalence estimates could be studied powerfully only for two disorder classes, any anxiety disorder (AUC = 0.88) and any mood disorder (AUC = 0.83). As with lifetime prevalence, 12‐month concordance improved when CIDI symptom‐level data were added to predict SCID diagnoses. CIDI 12‐month prevalence estimates were unbiased relative to SCID estimates. The validity of the CIDI is likely to be under‐estimated in these comparisons due to the fact that the reliability of the SCID diagnoses, which is presumably less than perfect, sets a ceiling on maximum CIDI‐SCID concordance. Copyright © 2006 John Wiley & Sons, Ltd.
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              Reliability and validity studies of the WHO--Composite International Diagnostic Interview (CIDI): a critical review.

              This paper reviews reliability and validity studies of the WHO - Composite International Diagnostic Interview (CIDI). The CIDI is a comprehensive and fully standardized diagnostic interview designed for assessing mental disorders according to the definitions of the Diagnostic Criteria for Research of ICD-10 and DSM-III-R. The instrument contains 276 symptom questions many of which are coupled with probe questions to evaluate symptom severity, as well as questions for assessing help-seeking behavior, psychosocial impairments, and other episode-related questions. Although primarily intended for use in epidemiological studies of mental disorders, it is also being used extensively for clinical and other research purposes. The review documents the wide spread use of the instrument and discusses several test-retest and interrater reliability studies of the CIDI. Both types of studies have confirmed good to excellent Kappa coefficients for most diagnostic sections. In international multicenter studies as well as several smaller center studies the CIDI was judged to be acceptable for most subjects and was found to be appropriate for use in different kinds of settings and countries. There is however still a need for reliability studies in general population samples, the area the CIDI was primary intended for. Only a few selected aspects of validity have been examined so far, mostly in smaller selected clinical samples. The need for further procedural validity studies of the CIDI with clinical instruments such as the SCAN as well as cognitive validation studies is emphasized. The latter should focus on specific aspects, such as the use of standardized questions in the elderly, cognitive probes to improve recall of episodes and their timing, as well as the role of order effects in the presentation of diagnostic sections.
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                Author and article information

                Contributors
                +1 613 901 9626 , Peter.Beliveau@forces.gc.ca
                Journal
                BMC Psychiatry
                BMC Psychiatry
                BMC Psychiatry
                BioMed Central (London )
                1471-244X
                22 May 2019
                22 May 2019
                2019
                : 19
                : 156
                Affiliations
                [1 ]ISNI 0000 0001 2295 5076, GRID grid.457399.5, Directorate of Mental Health, , Canadian Forces Health Services Group, ; 101 Colonel By Drive Carling Campus, Building 9, Ottawa, ON K1A 0K2 Canada
                [2 ]ISNI 0000 0001 2182 2255, GRID grid.28046.38, School of Epidemiology, Public Health and Preventive Medicine, , University of Ottawa, ; Ottawa, ON Canada
                [3 ]ISNI 0000 0001 2182 2255, GRID grid.28046.38, Department of Family Medicine, , University of Ottawa, ; Ottawa, ON Canada
                Author information
                http://orcid.org/0000-0002-7081-4769
                Article
                2146
                10.1186/s12888-019-2146-z
                6532170
                31117963
                84d17bf2-e490-4837-889d-9ec4077b862e
                © The Author(s). 2019

                Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

                History
                : 25 July 2018
                : 10 May 2019
                Categories
                Research Article
                Custom metadata
                © The Author(s) 2019

                Clinical Psychology & Psychiatry
                major depressive disorder,post-traumatic stress disorder,psychological trauma,logistic models,probability,military personnel

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