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      Adrenal Adenoma with 18-Hydroxycorticosterone Excess and Hypertension: A Variant of Aldosteronomas

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          Abstract

          A 46-year-old woman with hypertension, normokalemia, suppressed renin, normal catecholamines, and a left adrenal mass on the CT scan was found to have excessive 18-hydroxycorticosterone (18-OHB) and normal aldosterone levels in plasma, both of which responded poorly to sodium restriction and angiotension II, and supranormally to ACTH. Plasma 18-hydroxydeoxycorticosterone (18-OHDOC) was normal. After adrenalectomy, amelioration from hypertension occurred with a reduction in plasma 18-OHB and aldosterone. The plasma 18-OHDOC remained normal. The adrenal tumor was histologically an adenoma, containing a large amount of 18-OHB and a small amount of aldosterone. Thus, the present adenoma seems to be a variant of aldosteronomas.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1984
          1984
          26 November 2008
          : 19
          : 4
          : 224-231
          Affiliations
          Division of Endocrinology, Department of Internal Medicine, Kanazawa Medical University, Uchinada, Ishikawa, Japan
          Article
          179892 Horm Res 1984;19:224–231
          10.1159/000179892
          6745843
          © 1984 S. Karger AG, Basel

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          Pages: 8
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