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Abstract

Fosmidomycin is a promising antimalarial drug candidate with a unique chemical structure and a novel mode of action. Chain substituted pivaloyloxymethyl ester derivatives of Fosmidomycin and its acetyl analogue FR900098 have been synthesized and their in vitro antimalarial activity versus the Chloroquine sensitive strain 3D7 of Plasmodium falciparum has been determined.

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PubMed ID:: 16679022

DOI:: 10.1016/j.bmc.2006.04.018

ScienceOpen disciplines: Chemistry

Keywords: Animals,Antimalarials,chemical synthesis,chemistry,pharmacology,Dose-Response Relationship, Drug,Fosfomycin,analogs & derivatives,Molecular Structure,Parasitic Sensitivity Tests,Pentanoic Acids,Plasmodium falciparum,classification,drug effects,growth & development,Prodrugs,Stereoisomerism,Structure-Activity Relationship

Synthesis and antimalarial activity of chain substituted pivaloyloxymethyl ester analogues of Fosmidomycin and FR900098.

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