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      Coordination polymer coated mesoporous silica nanoparticles for pH-responsive drug release.

      Advanced Materials (Deerfield Beach, Fla.)
      Drug Delivery Systems, Hydrogen-Ion Concentration, Nanoparticles, chemistry, Particle Size, Polymers, chemical synthesis, Porosity, Silicon Dioxide, Surface Properties, Topotecan

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          Abstract

          Coordination polymer coated mesoporous silica nanoparticles for drug delivery are successfully synthesized. The system ensures that drugs are stored in the mesopores under a physiological environment. Upon H(+) stimulus in the endosomal and lysosomal compartments, the drugs are released into the intracellular organelles of cancer cells, effectively killing the cells. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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