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      Differing Patterns of Renal Vein Renin Secretion in Patients with Renovascular Hypertension, and Their Role in Predicting the Response to Angioplasty

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          Abstract

          The correlation between the arteriographic appearance and functional significance of renal artery stenosis in hypertensive patients is poor. Measurements of renal vein renin in patients with unilateral renal artery stenosis undergoing renal angioplasty show that before angioplasty there is lateralization of renin secretion to the ischemic kidney, with suppression from the contralateral kidney. Following angioplasty this pattern returns to normal, with both kidneys showing similar increments of renin in the renal veins. The prediction of therapeutic outcome from renal vein renin measurements is more reliable (sensitivity 74%, specificity 100%) when expressed as the increment of renin for each renal vein over the inferior vena caval value than as the ratio between the two renal veins (sensitivity 62%, specificity 60%), but there is a high false-negative rate with both methods. Renal vein renin patterns cannot reliably distinguish between unilateral and bilateral renal artery stenosis, and in patients with bilateral stenoses tend to show lateralization to the more ischemic kidney.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          978-3-8055-4387-3
          978-3-318-01793-9
          1660-8151
          2235-3186
          1986
          1986
          05 December 2008
          : 44
          : Suppl 1
          : 8-11
          Affiliations
          Cardiovascular Center, The New York Hospital-Cornell University Medical College, New York, USA
          Article
          184037 Nephron 1986;44:8–11
          10.1159/000184037
          2944019
          © 1986 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 4
          Categories
          New Diagnostic Aspects in Renovascular Hypertension

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