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      Wireless Recording in the Peripheral Nervous System with Ultrasonic Neural Dust

      , , , , , , ,
      Neuron
      Elsevier BV

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          Abstract

          The emerging field of bioelectronic medicine seeks methods for deciphering and modulating electrophysiological activity in the body to attain therapeutic effects at target organs. Current approaches to interfacing with peripheral nerves and muscles rely heavily on wires, creating problems for chronic use, while emerging wireless approaches lack the size scalability necessary to interrogate small-diameter nerves. Furthermore, conventional electrode-based technologies lack the capability to record from nerves with high spatial resolution or to record independently from many discrete sites within a nerve bundle. Here, we demonstrate neural dust, a wireless and scalable ultrasonic backscatter system for powering and communicating with implanted bioelectronics. We show that ultrasound is effective at delivering power to mm-scale devices in tissue; likewise, passive, battery-less communication using backscatter enables high-fidelity transmission of electromyogram (EMG) and electroneurogram (ENG) signals from anesthetized rats. These results highlight the potential for an ultrasound-based neural interface system for advancing future bioelectronics-based therapies.

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          Author and article information

          Journal
          Neuron
          Neuron
          Elsevier BV
          08966273
          August 2016
          August 2016
          : 91
          : 3
          : 529-539
          Article
          10.1016/j.neuron.2016.06.034
          27497221
          84f64629-09aa-473b-97e2-a3d97ac14afc
          © 2016

          https://www.elsevier.com/tdm/userlicense/1.0/

          https://www.elsevier.com/open-access/userlicense/1.0/

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