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      Immune interferon: a pleiotropic lymphokine with multiple effects.

      1 ,
      Immunology today
      Elsevier BV

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          Abstract

          Immune (gamma) interferon (IFN-γ) is produced during an immune response by antigen-specific T cells and probably also by natural killer (NK) cells recruited by the T cell-product interleukin 2 (IL-2). IFN-γ was discovered and originally measured on the basis of its anti-viral activity, but its complex anti-cellular activities probably reflect its biological role more clearly. In this review, Giorgio Trinchieri and Bice Perussia discuss some aspects of the biology of IFN-γ, its pleiomorphic anti-cellular effects and its ability to modulate cellular responses to other regulatory factors.

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          Author and article information

          Journal
          Immunol. Today
          Immunology today
          Elsevier BV
          0167-5699
          0167-5699
          Apr 1985
          : 6
          : 4
          Affiliations
          [1 ] The Wistar Institute of Anatomy and Biology, 36th Street Spruce, Philadelphia PA 19104, USA.
          Article
          0167-5699(85)90080-5
          10.1016/0167-5699(85)90080-5
          25289500
          84f832ba-e2e3-46da-9773-62a184960f9a
          History

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