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      Non-histaminergic angioedema: focus on bradykinin-mediated angioedema.

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          Abstract

          Angioedema is a result of increased vascular permeability, with subsequent extravasation of intravascular fluid into the surrounding tissues. Angioedema may be mediated by histamine, bradykinin or other mediators. Histaminergic angioedema generally presents with urticaria and/or pruritus and will respond to conventional treatment with antihistamines, corticosteroids or epinephrine. Bradykinin-mediated angioedema, which includes hereditary angioedema (HAE types I, II and III), acquired C1-INH deficiency, and angiotensin-converting enzyme inhibitor-induced angioedema does not typically present with urticaria/weals and does not respond to conventional agents such as antihistamines or corticosteroids. In recent years, several agents that prevent the generation or activity of bradykinin have been developed for the treatment of HAE types I and II and are also being evaluated in other types of bradykinin-mediated angioedema. These agents have the potential to improve outcomes for patients with different forms of bradykinin-mediated angioedema.

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          Author and article information

          Journal
          Clin. Exp. Allergy
          Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
          Wiley
          1365-2222
          0954-7894
          Apr 2013
          : 43
          : 4
          Affiliations
          [1 ] Clinical Immunology, Mount Sinai School of Medicine, New York, NY 10029, USA. paula.busse@mssm.edu
          Article
          10.1111/cea.12019
          23517034
          85028a40-66f3-4f17-aa39-533fd9899774
          History

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