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      Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms.

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          Abstract

          Neurofibrillary tangles are composed of insoluble aggregates of the microtubule-associated protein tau. In Alzheimer's disease the accumulation of neurofibrillary tangles occurs in the absence of tau mutations. Here we present mice that develop pathology from non-mutant human tau, in the absence of other exogenous factors, including beta-amyloid. The pathology in these mice is Alzheimer-like, with hyperphosphorylated tau accumulating as aggregated paired helical filaments. This pathologic tau accumulates in the cell bodies and dendrites of neurons in a spatiotemporally relevant distribution.

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          Author and article information

          Journal
          J Neurochem
          Journal of neurochemistry
          Wiley
          0022-3042
          0022-3042
          Aug 2003
          : 86
          : 3
          Affiliations
          [1 ] Departments of Neuroscience and Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.
          Article
          1879
          10.1046/j.1471-4159.2003.01879.x
          12859672
          850609b8-54cc-4653-93b2-ccbc620bc30c

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