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      Long-term toxicity/activity profile of 2',3'-dideoxyinosine in AIDS or AIDS-related complex.

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          Abstract

          To evaluate the long-term toxicity and activity profile of 2',3'-dideoxyinosine (ddI), a potent inhibitor of human immunodeficiency virus (HIV) replication, in vitro. 58 patients with AIDS or AIDS-related complex were studied with additional reference to the effect of previous treatment with zidovudine, and the effect of ddI on HIV-induced cognitive dysfunction. Doses above 9.6 mg/kg per day of ddI were frequently associated with toxicity (peripheral neuropathy, pancreatitis, or hepatitis). Doses of 9.6 mg/kg per day or below were well tolerated for up to 21 months. A subset of patients receiving 3.2-9.6 mg/kg per day of ddI had long-term immunological improvement and reduction of serum HIV p24 antigen. Immunological changes were especially seen in patients who had little previous zidovudine therapy. 5 patients with HIV-induced cognitive impairment improved with ddI. Thus, ddI may have anti-HIV activity at doses which are tolerated for long-term therapy, although pancreatitis could be a life-threatening complication.

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          Author and article information

          Journal
          Lancet
          Lancet (London, England)
          0140-6736
          0140-6736
          Sep 01 1990
          : 336
          : 8714
          Affiliations
          [1 ] Clinical Oncology Program, National Cancer Institute, Bethesda, MD 20892.
          0140-6736(90)92085-V
          1975038

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