Effect of Captopril Therapy on Lymphocyte Potassium and Magnesium Concentrations in Patients with Congestive Heart Failure

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Abstract

Lymphocyte potassium and magnesium were measured before and 3 months after the introduction of captopril in 18 patients taking diuretics for congestive heart failure. Compared to 32 healthy controls, 9 patients who had been on potassium supplements plus frusemide had decreased baseline lymphocyte magnesium and potassium concentrations (p < 0.01), in spite of similar plasma electrolyte levels. There was a significant (p < 0.01) increase in both lymphocyte potassium and magnesium levels after 3 months’ treatment with captopril and frusemide in these patients. Nine patients who had been taking a potassium-sparing combination diuretic also had an increase in lymphocyte magnesium (p < 0.05) following the introduction of captopril. Increased intracellular potassium and magnesium may be one mechanism whereby angiotensin-converting enzyme inhibitors reduce arrhythmias and improve survival in patients with congestive heart failure.

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Journal ID (publisher-id): CRD

Journal ID (nlm-ta): Cardiology

Journal ID (doi): 10.1159/issn.0008-6312

Title: Cardiology

Publisher: S. Karger AG

ISSN (Print): 0008-6312

ISSN (Electronic): 1421-9751

Publication date Subscription-year: 1992

Publication date (Print): 1992

Publication date (Electronic): 12 November 2008

Volume: 80

Issue: 2

Pages: 100-105

Affiliations

Departments of ^aCardiology and ^bBiochemistry, University College Hospital, Galway, Ireland

Article

Publisher ID: 174986 Other ID: Cardiology 1992;80:100–105

DOI: 10.1159/000174986

PubMed ID: 1611628

SO-VID: 851c5448-b7c1-4fc1-8ea0-4159eb5b38ee

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 04 October 1991

Date accepted : 23 October 1991

Page count

Pages: 6

Effect of Captopril Therapy on Lymphocyte Potassium and Magnesium Concentrations in Patients with Congestive Heart Failure

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Karger: Cardiovascular System

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