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      Effect of Negative Pressure Wound Therapy vs Standard Wound Management on 12-Month Disability Among Adults With Severe Open Fracture of the Lower Limb : The WOLLF Randomized Clinical Trial

      1 , 2 , 3 , 2 , 1 , 1 , 2 , 1 , 1 , 2 , 4 , for the UK WOLLF Collaboration
      JAMA
      American Medical Association (AMA)

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          Abstract

          Open fractures of the lower limb occur when a broken bone penetrates the skin. There can be major complications from these fractures, which can be life-changing.

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          Most cited references14

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          Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones

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            The Disability Rating Index: an instrument for the assessment of disability in clinical settings.

            The purpose of this study was to evaluate an instrument for assessment of physical disability, mainly intended for clinical settings, the Disability Rating Index (DRI). Healthy persons (n = 1092), both white and blue collar workers, and patients (n = 366) with different levels of physical capacity, were assessed. Most of the patients (n = 303) underwent rehabilitation programmes for neck/shoulder/low-back pain but some (n = 47) were arthritis patients waiting for hip or knee replacement surgery, or wheelchair patients with multiple sclerosis (n = 16). The reliability was investigated by test-retest studies, intra- and inter-rater and internal consistency studies. Five construct validity tests were carried out: a discrimination study; a converging validity test; a test for sensitivity to small alterations in health status; and two correlational validity tests. Correlation of the self-reported DRI to the actual performance in similar activities was carried out. Responsiveness was tested by correlation of the DRI before/after replacement surgery for arthritis. The test-retest correlations were 0.83-0.95 in the studies, including correlation of different versions. The intra- and inter-rater reproducibility was 0.98 and 0.99 respectively. The Kruskal-Wallis test in the discrimination study yielded p < 0.0001. More than 90% of the respondents completed the questionnaire correctly. Correlation of the DRI to the Functional Status Questionnaire was 0.46. The responsiveness was excellent, p = 0.0001. The DRI proved to be a robust, practical clinical and research instrument with good responsiveness and acceptability for assessment of disability caused by impairment of common motor functions.
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              Assessment of the SF-36 version 2 in the United Kingdom

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                Author and article information

                Journal
                JAMA
                JAMA
                American Medical Association (AMA)
                0098-7484
                June 12 2018
                June 12 2018
                : 319
                : 22
                : 2280
                Affiliations
                [1 ]Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Gibbet Hill Campus, Coventry, United Kingdom
                [2 ]Oxford Trauma, Nuffield Department of Orthopaedics, Rheumatology & Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom
                [3 ]University Hospitals Coventry and Warwickshire NHS Trust, Coventry, United Kingdom
                [4 ]Statistics and Epidemiology Unit, Warwick Medical School, University of Warwick, Gibbet Hill Campus, Coventry, United Kingdom
                Article
                10.1001/jama.2018.6452
                6583504
                29896626
                8525aad5-03c6-4107-9c0a-cd3f4aba90fe
                © 2018
                History

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