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      Future directions for peptide therapeutics development.

      1 ,
      Drug discovery today
      Elsevier BV

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          Abstract

          The notable expansion of peptide therapeutics development in the late 1990s and the 2000s led to an unprecedented number of marketing approvals in 2012 and has provided a robust pipeline that should deliver numerous approvals during the remainder of the 2010s. To document the current status of the pipeline, we collected data for peptide therapeutics in clinical studies and regulatory review, as well as those recently approved. In this Foundation review, we provide an overview of the pipeline, including therapeutic area and molecular targets, with a focus on glucagon-like peptide 1 receptor agonists. Areas for potential expansion, for example constrained peptides and peptide-drug conjugates, are profiled.

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          Author and article information

          Journal
          Drug Discov Today
          Drug discovery today
          Elsevier BV
          1878-5832
          1359-6446
          Sep 2013
          : 18
          : 17-18
          Affiliations
          [1 ] CovX/Pfizer Worldwide Research and Development, 9381 Judicial Drive, Suite 200, San Diego, CA 92121, USA.
          Article
          S1359-6446(13)00157-8
          10.1016/j.drudis.2013.05.011
          23726889
          8551b18b-b4fc-448a-9430-5f94f9da9ea2
          Copyright © 2013 Elsevier Ltd. All rights reserved.
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