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      Circadian Rhythms and Coronary Events: Implications for Therapy

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      Cardiology

      S. Karger AG

      Therapy, Circadian rhythm, Coronary events

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          Abstract

          Obstructive coronary disease has many clinical expressions and some are used as useful indicators of risk. Apart from symptoms, transient ischaemia occurs during daily life, is mostly silent and represents one measure of risk. Ambulatory monitoring of the electrocardiogram shows that ischaemia occurs with increased frequency during the morning hours while waking and rising. This coincides with other damaging vascular events, increased sympathetic activity and changes in coronary blood supply and myocardial oxygen demand that may favour a lower threshold to ischaemia. Calcium blockers, β-blockers and aspirin can favourably affect this process and long-acting drugs appear to be a more rational approach given the variability of ischaemia over time.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          978-3-8055-5613-2
          978-3-318-01670-3
          0008-6312
          1421-9751
          1992
          1992
          12 November 2008
          : 80
          : Suppl 1
          : 23-25
          Affiliations
          Brigham & Women’s Hospital, Department of Medicine, Boston, Mass., USA
          Article
          175044 Cardiology 1992;80:23–25
          10.1159/000175044
          1600537
          © 1992 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 3
          Categories
          Session I

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