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      Effect of capsaicin on plasma and tissue levels of insulin-like growth factor-I in spontaneously hypertensive rats.

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          Abstract

          Plasma levels of insulin-like growth factor-I (IGF-I), an important substance for maintaining cardiovascular homeostasis, are lower in spontaneously hypertensive rats (SHR) than in normotensive Wistar Kyoto rats (WKY). Calcitonin gene-related peptide (CGRP) increases IGF-I production in vitro and in vivo, suggesting that stimulation of sensory neurons might increase the production of IGF-I in SHR.

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          Author and article information

          Journal
          Growth Horm. IGF Res.
          Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
          Elsevier BV
          1096-6374
          1096-6374
          Feb 2008
          : 18
          : 1
          Affiliations
          [1 ] Department of Translational Medical Science Research, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan.
          Article
          S1096-6374(07)00089-5
          10.1016/j.ghir.2007.06.004
          17693108
          85643946-9e7d-43f4-8607-e24e78407bb1
          History

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