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      Plasmapheresis and intravenous immune globulin provides effective rescue therapy for refractory humoral rejection and allows kidneys to be successfully transplanted into cross-match-positive recipients.

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          Abstract

          Hyperacute rejection (HAR) and acute humoral rejection (AHR) remain recalcitrant conditions without effective treatments, and usually result in graft loss. Plasmapheresis (PP) has been shown to remove HLA- specific antibody (Ab) in many different clinical settings. Intravenous gamma globulin (IVIG) has been used to suppress alloantibody and modulate immune responses. Our hypothesis was that a combination of PP and IVIG could effectively and durably remove donor-specific, anti-HLA antibody (Ab), rescuing patients with established AHR and preemptively desensitizing recipients who had positive crossmatches with a potential live donor.

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          Author and article information

          Journal
          Transplantation
          Transplantation
          Ovid Technologies (Wolters Kluwer Health)
          0041-1337
          0041-1337
          Sep 27 2000
          : 70
          : 6
          Affiliations
          [1 ] Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
          Article
          10.1097/00007890-200009270-00006
          11014642
          858b8cf1-a7a6-472d-86ef-3a8eab59cad8
          History

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