Prospective of  68 Ga Radionuclide Contribution to the Development of Imaging Agents for Infection and Inflammation

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Abstract

During the last decade, the utilization of ⁶⁸Ga for the development of imaging agents has increased considerably with the leading position in the oncology. The imaging of infection and inflammation is lagging despite strong unmet medical needs. This review presents the potential routes for the development of ⁶⁸Ga-based agents for the imaging and quantification of infection and inflammation in various diseases and connection of the diagnosis to the treatment for the individualized patient management.

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Most cited references 264

Record: found
Abstract: found
Article: not found

Microbiological effects of sublethal levels of antibiotics.

Dan Andersson, Diarmaid Hughes (2014)

The widespread use of antibiotics results in the generation of antibiotic concentration gradients in humans, livestock and the environment. Thus, bacteria are frequently exposed to non-lethal (that is, subinhibitory) concentrations of drugs, and recent evidence suggests that this is likely to have an important role in the evolution of antibiotic resistance. In this Review, we discuss the ecology of antibiotics and the ability of subinhibitory concentrations to select for bacterial resistance. We also consider the effects of low-level drug exposure on bacterial physiology, including the generation of genetic and phenotypic variability, as well as the ability of antibiotics to function as signalling molecules. Together, these effects accelerate the emergence and spread of antibiotic-resistant bacteria among humans and animals.

0 comments Cited 493 times – based on 0 reviews      Review now

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Record: found
Abstract: found
Article: not found

Inverse electron demand Diels-Alder reactions in chemical biology.

B L Oliveira, Z Guo, G Bernardes (2017)

The emerging inverse electron demand Diels-Alder (IEDDA) reaction stands out from other bioorthogonal reactions by virtue of its unmatchable kinetics, excellent orthogonality and biocompatibility. With the recent discovery of novel dienophiles and optimal tetrazine coupling partners, attention has now been turned to the use of IEDDA approaches in basic biology, imaging and therapeutics. Here we review this bioorthogonal reaction and its promising applications for live cell and animal studies. We first discuss the key factors that contribute to the fast IEDDA kinetics and describe the most recent advances in the synthesis of tetrazine and dienophile coupling partners. Both coupling partners have been incorporated into proteins for tracking and imaging by use of fluorogenic tetrazines that become strongly fluorescent upon reaction. Selected notable examples of such applications are presented. The exceptional fast kinetics of this catalyst-free reaction, even using low concentrations of coupling partners, make it amenable for in vivo radiolabelling using pretargeting methodologies, which are also discussed. Finally, IEDDA reactions have recently found use in bioorthogonal decaging to activate proteins or drugs in gain-of-function strategies. We conclude by showing applications of the IEDDA reaction in the construction of biomaterials that are used for drug delivery and multimodal imaging, among others. The use and utility of the IEDDA reaction is interdisciplinary and promises to revolutionize chemical biology, radiochemistry and materials science.

0 comments Cited 226 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Imaging and cancer: a review.

Leonard Fass (2008)

Multiple biomedical imaging techniques are used in all phases of cancer management. Imaging forms an essential part of cancer clinical protocols and is able to furnish morphological, structural, metabolic and functional information. Integration with other diagnostic tools such as in vitro tissue and fluids analysis assists in clinical decision-making. Hybrid imaging techniques are able to supply complementary information for improved staging and therapy planning. Image guided and targeted minimally invasive therapy has the promise to improve outcome and reduce collateral effects. Early detection of cancer through screening based on imaging is probably the major contributor to a reduction in mortality for certain cancers. Targeted imaging of receptors, gene therapy expression and cancer stem cells are research activities that will translate into clinical use in the next decade. Technological developments will increase imaging speed to match that of physiological processes. Targeted imaging and therapeutic agents will be developed in tandem through close collaboration between academia and biotechnology, information technology and pharmaceutical industries.

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Author and article information

Contributors

Irina Velikyan:

ORCID: http://orcid.org/0000-0001-5315-6090

Journal

Journal ID (nlm-ta): Contrast Media Mol Imaging

Journal ID (iso-abbrev): Contrast Media Mol Imaging

Journal ID (publisher-id): CMMI

Title: Contrast Media & Molecular Imaging

Publisher: Hindawi

ISSN (Print): 1555-4309

ISSN (Electronic): 1555-4317

Publication date Collection: 2018

Publication date (Electronic): 4 January 2018

Volume: 2018

Electronic Location Identifier: 9713691

Affiliations

¹Section of Nuclear Medicine and PET, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden

²Preclinical PET Platform, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden

³PET Centre, Centre for Medical Imaging, Uppsala University Hospital, 75185 Uppsala, Sweden

Author notes

Academic Editor: Xiang-Guo Li

Author information

Irina Velikyan http://orcid.org/0000-0001-5315-6090

Article

DOI: 10.1155/2018/9713691

PMC ID: 5817300

PubMed ID: 29531507

SO-VID: 85b013e3-a63a-4108-980f-da3b469bcd09

License:

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

History

Date received : 17 September 2017

Date revision received : 19 November 2017

Date accepted : 10 December 2017

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