Urine and Serum Levels of the Carboxyterminal Domain (NCI) of Collagen IV in Membranous Glomerulonephritis and Diabetic Nephropathy

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Abstract

Serum and urinary concentrations of NCI, the non collagenous globular domain of collagen IV, were used as markers for turnover of basement membranes. NCI levels were studied in membranous glomerulonephritis and diabetic nephropathy. Thirteen patients with membranous glomerulonephritis and 8 insulin-dependent diabetic patients with diabetic nephropathy were compared to 16 apparently healthy control subjects. The patients with membranous glomerulonephritis had lower levels of NCI in serum and urine compared to the control subjects. In comparison, the patients with diabetic nephropathy had similar levels of NCI in serum and urine as the control subjects. Furthermore, among patients with membranous glomerulonephritis, those with hypertension had higher serum levels of NCI than those without, which may indicate that hemodynamic factors influence the basement membrane collagen metabolism. It is suggested that there are differences in basement membrane turnover in membranous glomerulonephritis and diabetic nephropathy although there are similarities in glomerular histopathological features. Other possible mechanism are discussed. Further studies are needed to confirm the suggested mechanism.

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Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1991

Publication date (Print): 1991

Publication date (Electronic): 11 December 2008

Volume: 59

Issue: 1

Pages: 15-20

Affiliations

Department of ^aInternal Medicine, ^bNephrology and ^cClinical Pathology, University Hospital, Lund, Sweden

Article

Publisher ID: 186511 Other ID: Nephron 1991;59:15–20

DOI: 10.1159/000186511

PubMed ID: 1944730

SO-VID: 85c995eb-3fcf-4ec2-a8f5-08b301f0a807

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date accepted : 30 October 1990

Page count

Pages: 6

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