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      Schistosoma mansoni: evaluation of the activity of oxamniquine on schistosomules, at 24 hours after infection Translated title: Schistosoma mansoni: avaliação da atividade da oxamniquina (Mansil*) em esquistossômulos com 24 horas após infecção

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          Abstract

          Mice transcutaneously infected with about 400 cercariae were submitted to treatment with oxamniquine (400 mg/kg), 24 hours after infection. The recovery of schistosomules, at 4, 24, 48 and 72 hours and 35 days after treatment, showed the activity of the drug on the parasites, thus practically preventing their migration from the skin to the lungs. Worm recovery performed in the lungs (96 hours after treatment) showed recovery means of 0.6 worms/mouse in the treated group and 53.8 in the control group (untreated). The perfusion of the portal system carried out at 35 days after treatment clearly showed the elimination of all the parasites in the treated group, whereas a recovery mean of 144.7 worms/mouse was detected in the control group (untreated). These findings confirm the efficacy of oxamniquine at the skin phase of infection, and also show similarity with the immunization method that uses irradiated cercariae. The practical application of these findings in the medical clinic is discussed too

          Translated abstract

          Camundongos infectados transcutaneamente com cerca de 400 cercárias foram submetidos a tratamento com oxamniquina (400 mg/kg), 24 horas após a infecção. A recuperação dos esquistossômulos a nível da pele mostrou a atividade da droga nos parasitos e impediu praticamente sua migração para os pulmões. A recuperação a nível pulmonar (96 horas após tratamento) mostrou uma média de 0,6 vermes por camundongo no grupo tratado e 53,8 no grupo controle, não tratado. A perfusão do sistema porta, realizada aos 35 dias após infecção, mostrou claramente a eliminação de todos os parasitos no grupo tratado, enquanto foi recuperada uma média de 144,7 vermes no grupo controle, não tratado. Estes achados vem comprovar a eficácia da oxamniquina na fase cutânea da infecção e mostra analogia com o sistema de imunização que usa cercárias irradiadas. Também se discute a aplicação destes resultados na clínica

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          Most cited references38

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          Experiência com quimioterapia em grande escala no controle da esquistossomose no Brasil

          N Katz, N. KATZ (1980)
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            The immunopathogenesis of schistosomiasis: A multidisciplinary approach

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              • Abstract: not found
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              The immunopathogenesis of schistosomiasis: a multidisciplinary approach.

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                Author and article information

                Journal
                rimtsp
                Revista do Instituto de Medicina Tropical de São Paulo
                Rev. Inst. Med. trop. S. Paulo
                Instituto de Medicina Tropical (São Paulo, SP, Brazil )
                1678-9946
                December 1993
                : 35
                : 6
                : 557-561
                Affiliations
                [02] Belo Horizonte MG orgnameUniversidade Federal de Minas Gerais orgdiv1Faculdade de Farmácia orgdiv2Departamento de Análises Clínicas e Toxicológicas Brasil
                [01] Belo Horizonte MG orgnameUniversidade Federal de Minas Gerais orgdiv1Instituto de Ciências Biológicas orgdiv2Departamento de Parasitologia Brasil
                Article
                S0036-46651993000600013 S0036-4665(93)03500613
                10.1590/S0036-46651993000600013
                85ce5dc6-a5fd-43db-897a-ba0df8ed340b

                This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

                History
                : 26 July 1993
                : 26 April 1993
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 26, Pages: 5
                Product

                SciELO Brazil

                Categories
                Therapeutic trial

                Schistosoma mansoni,Schistosomules,Migration,Chemotherapeutic treatment,Oxamniquine

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