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      Antibodies against Testosterone: Valuable Tools for the Investigation of the Hypothalamo-Pituitary-Gonadal System in the Rabbit Fetus

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      Hormone Research in Paediatrics

      S. Karger AG

      Regulation, Leydig cells, Fetus, Immunization, Testosterone

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          16 female rabbits were actively immunized against testosterone (T). 9 of them conceived and gave birth to 89 neonates. In all neonatal plasma samples antibodies against T were detected. In the males the plasma T levels were elevated 1,000-fold. The testes of these animals were examined by means of morphometrical and biochemical methods. The results indicate increased stimulation of Leydig cells in fetuses exposed to antibodies against T, and suggest that even in the fetus a negative feedback is acting between testes and hypothalamo-pituitary system, which is interrupted by the antibodies which bind and inactivate T.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          25 November 2008
          : 13
          : 1
          : 16-27
          Division of Pediatric Endocrinology, Children’s Hospital of the University of Munich, Munich, and Main Laboratory of Schering AG, Berlin
          179267 Horm Res 1980;13:16–27
          © 1980 S. Karger AG, Basel

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          Pages: 12
          Original Paper


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