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      Study of Renal Metabolic Disturbances Related to Renal Lithiasis at School Age in Very-Low-Birth-Weight Children

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          Abstract

          We studied 34 asymptomatic children who were born with a very-low-birth-weight (VLBW) and had no perinatal history of acute renal failure nor treatment with furosemide. The study was done at preschool or school age, looking for echographic changes and renal tubular disturbances which are known to predispose to renal lithiasis. The results were compared with those of a control group of 18 children who had been born at term with a body weight >2,500 g. One or more renal tubular disturbances were found in 64.70% of the VLBW children. Most frequently found were decreased ammonium excretion in response to furosemide (38.23%), enhanced N-acetylglucosaminidase excretion (35.29%), hypercalciuria (26.47%), and hypocitraturia (23.53%). Echography revealed renal cortical hyperechogenicity (17.65%) and renal lithiasis (8.82%) in some of the VLBW children. We found a significant positive correlation (r = 0.7) between the perinatal level of plasma phosphate and the total amount of H<sup>+</sup> excreted in response to furosemide at preschool or school age. Because these renal tubular anomalies may be precursors of future lithiasis, and the renal function and echography tests are not invasive, we suggest that renal tubular function be measured and followed up in every VLBW child, particularly when perinatal hypophosphatemia has occurred.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1998
          July 1998
          22 June 1998
          : 79
          : 3
          : 269-273
          Affiliations
          a La Laguna University, San Cristóbal de la Laguna, b Pediatric Nephrology Unit, c Clinical Laboratory, and d Neonatology Unit, Nuestra Señora de la Candelaria Hospital, Santa Cruz de Tenerife, Spain; e Albert Einstein College of Medicine, New York, N.Y., USA
          Article
          45048 Nephron 1998;79:269–273
          10.1159/000045048
          9678425
          © 1998 S. Karger AG, Basel

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          Page count
          Pages: 5
          Product
          Self URI (application/pdf): https://www.karger.com/Article/Pdf/45048
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