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      Effects of Aloe vera cream on chronic anal fissure pain, wound healing and hemorrhaging upon defection: a prospective double blind clinical trial.

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          Abstract

          Aloe vera is a medicinal plant that promotes wound healing in burn injuries. A prospective clinical trial was conducted to evaluate the effects of a topical cream containing 0.5% Aloe vera juice powder in the treatment of chronic anal fissures. The aloe cream was applied by the patients to the wound site 3 times per day for 6 weeks following the instructions of a physician. Pain was assessed with a visual analog scale before treatment and at the end of each week of treatment. Wound healing and the amount and severity of bleeding were examined and evaluated before and at the end of each week of treatment. There were statistically significant differences in chronic anal fissure pain, hemorrhaging upon defection and wound healing before and at the end of the first week of treatment also in comparison with control group (p < 0.0001). In this study, a topical cream containing aloe vera juice was an effective treatment for chronic anal fissures. This is a promising result indicating that further comparative studies are justified.

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          Author and article information

          Journal
          Eur Rev Med Pharmacol Sci
          European review for medical and pharmacological sciences
          2284-0729
          1128-3602
          2014
          : 18
          : 7
          Affiliations
          [1 ] Department of Surgery, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. SaraAssadpour@yahoo.com.
          Article
          24763890

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