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      Measurement of Glomerular FiltrationRate by the 99m< /sup>Tc-DTPA Renogram Is Less Precise than Measured and Predicted Creatinine Clearance

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          Abstract

          The work was devised to compare measurements of glomerular filtration rate (GFR) by technetium-99m-diethylenetriaminepentacetic acid (<sup>99m</sup>Tc-DTPA) renogram to those by creatinine clearance (measured and predicted by Cockroft and Gault) and by inulin clearance. A total number of 65 individuals were enrolled: 15 healthy controls and 50 patients with renal disease. Compared to inulin clearance used as the gold standard, <sup>99m</sup>Tc-DTPA overestimated at low and underestimated at high GFRs. <sup>99m</sup>Tc-DTPA measurements were less precise than creatinine clearance except for individuals with GFR >100 ml/min × 1.73 m<sup>2</sup>. Measured creatinine clearance had the highest correlation coefficient with inulin clearance, <sup>99m</sup>Tc-DTPA clearance the lowest. In correlation analyses, 81.5% of the interindividual variability for measured creatinine clearance could be explained by true differences in inulin clearance; this value dropped to 59.1 and 57.4% for predicted creatinine clearance and <sup>99m</sup>Tc-DTPA, respectively. In patients with GFR <25 ml/min × 1.73 m<sup>2</sup>, all <sup>99m</sup>Tc-DTPA measurements were out of the 95% confidence interval for the inulin measurement. It can be inferred that <sup>99m</sup>Tc-DTPA clearance from the renogram is less precise than measured and predicted creatinine clearance.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1999
          1999
          10 February 1999
          : 81
          : 2
          : 136-140
          Affiliations
          Chairs of aNephrology and bNuclear Medicine, Second University of Naples, and cNuclear Medicine, ‘Federico II’ University of Naples, Italy
          Article
          45268 Nephron 1999;81:136–140
          10.1159/000045268
          9933747
          © 1999 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Figures: 4, Tables: 4, References: 11, Pages: 5
          Product
          Self URI (application/pdf): https://www.karger.com/Article/Pdf/45268
          Categories
          Original Paper

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