Measurement of Glomerular FiltrationRate by the ^99m< /sup>Tc-DTPA Renogram Is Less Precise than Measured and Predicted Creatinine Clearance

Abstract

The work was devised to compare measurements of glomerular filtration rate (GFR) by technetium-99m-diethylenetriaminepentacetic acid (^99mTc-DTPA) renogram to those by creatinine clearance (measured and predicted by Cockroft and Gault) and by inulin clearance. A total number of 65 individuals were enrolled: 15 healthy controls and 50 patients with renal disease. Compared to inulin clearance used as the gold standard, ^99mTc-DTPA overestimated at low and underestimated at high GFRs. ^99mTc-DTPA measurements were less precise than creatinine clearance except for individuals with GFR >100 ml/min × 1.73 m². Measured creatinine clearance had the highest correlation coefficient with inulin clearance, ^99mTc-DTPA clearance the lowest. In correlation analyses, 81.5% of the interindividual variability for measured creatinine clearance could be explained by true differences in inulin clearance; this value dropped to 59.1 and 57.4% for predicted creatinine clearance and ^99mTc-DTPA, respectively. In patients with GFR <25 ml/min × 1.73 m², all ^99mTc-DTPA measurements were out of the 95% confidence interval for the inulin measurement. It can be inferred that ^99mTc-DTPA clearance from the renogram is less precise than measured and predicted creatinine clearance.

Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1999

Publication date (Print): 1999

Publication date (Electronic): 10 February 1999

Volume: 81

Issue: 2

Pages: 136-140

Affiliations

Chairs of ^aNephrology and ^bNuclear Medicine, Second University of Naples, and ^cNuclear Medicine, ‘Federico II’ University of Naples, Italy

Article

Publisher ID: 45268 Other ID: Nephron 1999;81:136–140

DOI: 10.1159/000045268

PubMed ID: 9933747

Copyright statement: © 1999 S. Karger AG, Basel

License:

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Page count

Figures: 4, Tables: 4, References: 11, Pages: 5

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Categories

Subject: Original Paper