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      Measurement of Glomerular FiltrationRate by the 99m< /sup>Tc-DTPA Renogram Is Less Precise than Measured and Predicted Creatinine Clearance


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          The work was devised to compare measurements of glomerular filtration rate (GFR) by technetium-99m-diethylenetriaminepentacetic acid (<sup>99m</sup>Tc-DTPA) renogram to those by creatinine clearance (measured and predicted by Cockroft and Gault) and by inulin clearance. A total number of 65 individuals were enrolled: 15 healthy controls and 50 patients with renal disease. Compared to inulin clearance used as the gold standard, <sup>99m</sup>Tc-DTPA overestimated at low and underestimated at high GFRs. <sup>99m</sup>Tc-DTPA measurements were less precise than creatinine clearance except for individuals with GFR >100 ml/min × 1.73 m<sup>2</sup>. Measured creatinine clearance had the highest correlation coefficient with inulin clearance, <sup>99m</sup>Tc-DTPA clearance the lowest. In correlation analyses, 81.5% of the interindividual variability for measured creatinine clearance could be explained by true differences in inulin clearance; this value dropped to 59.1 and 57.4% for predicted creatinine clearance and <sup>99m</sup>Tc-DTPA, respectively. In patients with GFR <25 ml/min × 1.73 m<sup>2</sup>, all <sup>99m</sup>Tc-DTPA measurements were out of the 95% confidence interval for the inulin measurement. It can be inferred that <sup>99m</sup>Tc-DTPA clearance from the renogram is less precise than measured and predicted creatinine clearance.

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          Author and article information

          S. Karger AG
          10 February 1999
          : 81
          : 2
          : 136-140
          Chairs of aNephrology and bNuclear Medicine, Second University of Naples, and cNuclear Medicine, ‘Federico II’ University of Naples, Italy
          45268 Nephron 1999;81:136–140
          © 1999 S. Karger AG, Basel

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          Page count
          Figures: 4, Tables: 4, References: 11, Pages: 5
          Self URI (application/pdf): https://www.karger.com/Article/Pdf/45268
          Self URI (text/html): https://www.karger.com/Article/FullText/45268
          Self URI (journal page): https://www.karger.com/SubjectArea/Nephrology
          Original Paper

          Cardiovascular Medicine,Nephrology
          99mTc-DTPA clearance,Renogram,Inulin clearance,Creatinine clearance,Predicted creatinine clearance


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