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      PEG-PBLG nanoparticle-mediated HSV-TK/GCV gene therapy for oral squamous cell carcinoma.

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          Abstract

          Previous studies revealed that drug-loaded poly(ethylene-glycol)-poly(gamma-benzyl-L-glutamate) (PEG-PBLG) nanoparticles exhibit favorable pharmacokinetic characteristics in the treatment of oral squamous cell carcinoma (OSCC). In this study, the characteristics and anticancer effect of herpes simplex virus thymidine kinase (HSV-TK)-loaded PEG-PBLG nanoparticles for OSCC were investigated.

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          Author and article information

          Journal
          Nanomedicine (Lond)
          Nanomedicine (London, England)
          Future Medicine Ltd
          1748-6963
          1743-5889
          Dec 2008
          : 3
          : 6
          Affiliations
          [1 ] Department of Oral & Maxillofacial Surgery, Guanghua College of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, 510055, PR China.
          Article
          10.2217/17435889.3.6.813
          19025455

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