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      EMERGING BIOLOGICAL PRINCIPLES OF METASTASIS

      research-article
      1 , 1 , 1 , 2
      Cell

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          Abstract

          Metastases account for the great majority of cancer-associated deaths, yet this complex process remains the least understood aspect of cancer biology. As the body of research concerning metastasis continues to grow at a rapid rate, the biological programs that underlie the dissemination and metastatic outgrowth of cancer cells are beginning to come into view. In this review we summarize the cellular and molecular mechanisms involved in metastasis, with a focus on carcinomas where the most is known, and highlight the general principles of metastasis that have begun to emerge.

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          Author and article information

          Journal
          0413066
          2830
          Cell
          Cell
          Cell
          0092-8674
          1097-4172
          1 December 2016
          09 February 2017
          09 February 2018
          : 168
          : 4
          : 670-691
          Affiliations
          [1 ]Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142
          [2 ]Department of Biology, Massachusetts Institute of Technology and the MIT Ludwig Center for Molecular Oncology, Cambridge, MA 02142
          Article
          PMC5308465 PMC5308465 5308465 nihpa832139
          10.1016/j.cell.2016.11.037
          5308465
          28187288
          85f8a2a9-ad94-44e6-bc19-ce8e8b18fcf0
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