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      Catecholestrogens and Induction of Sexual Behavior in the Ovariectomized Rat

      ,

      Neuroendocrinology

      S. Karger AG

      Catecholestrogens, Lordosis behavior, Ovariectomy

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          Abstract

          The ability of the catecholestrogens, 4-hydroxyestradiol (4-OHE2) and 2-hydroxyestradiol (2-OHE2) to induce lordosis in ovariectomized rats primed with progesterone was assessed following either short- or long-term exposure to the steroids. 4-OHE2 successfully induced lordosis whether administered as two bolus intrajugular injections separated by a 3-hour interval or continuously for 7 days via subcutaneously implanted osmotic minipumps. 2-OHE2, however, was ineffective under both conditions. When administered subcutaneously in conjunction with 3 days of estradiol benzoate (E2B) treatment, neither of the catecholestrogens exhibited any antiestrogenic effect as compared with the lordosis response to E2B alone. Likewise, simultaneous administration of 2-OHE2 did not significantly alter the response to intrajugular injections of estradiol (E2) or 4-OHE2. The results indicate that 4-OHE2 (but not 2-OHE2) mimicks the lordosis-inducing action of E2 and that neither catecholestrogen has any antiestrogenic effect in this behavioral test system.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1981
          1981
          26 March 2008
          : 32
          : 4
          : 225-228
          Affiliations
          Department of Obstetrics and Gynecology, McGill University, Montreal, Canada
          Article
          123163 Neuroendocrinology 1981;32:225–228
          10.1159/000123163
          7219675
          © 1981 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 4
          Categories
          Original Paper

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