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      Intestinal mucosal barrier function in health and disease.

      1
      Nature reviews. Immunology
      Springer Science and Business Media LLC

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          Abstract

          Mucosal surfaces are lined by epithelial cells. These cells establish a barrier between sometimes hostile external environments and the internal milieu. However, mucosae are also responsible for nutrient absorption and waste secretion, which require a selectively permeable barrier. These functions place the mucosal epithelium at the centre of interactions between the mucosal immune system and luminal contents, including dietary antigens and microbial products. Recent advances have uncovered mechanisms by which the intestinal mucosal barrier is regulated in response to physiological and immunological stimuli. Here I discuss these discoveries along with evidence that this regulation shapes mucosal immune responses in the gut and, when dysfunctional, may contribute to disease.

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          Author and article information

          Journal
          Nat Rev Immunol
          Nature reviews. Immunology
          Springer Science and Business Media LLC
          1474-1741
          1474-1733
          Nov 2009
          : 9
          : 11
          Affiliations
          [1 ] Department of Pathology, The University of Chicago, 5841 South Maryland, MC 1089, Chicago, Illinois 60637, USA. jturner@bsd.uchicago.edu
          Article
          nri2653
          10.1038/nri2653
          19855405
          8605f9e3-2d64-4e5c-bf24-b9a0837bc9f9
          History

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