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      Cofilin-2 phosphorylation and sequestration in myocardial aggregates: novel pathogenetic mechanisms for idiopathic dilated cardiomyopathy.

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          Abstract

          Recently, tangles and plaque-like aggregates have been identified in certain cases of dilated cardiomyopathy (DCM), traditionally labeled idiopathic (iDCM), where there is no specific diagnostic test or targeted therapy. This suggests a potential underlying cause for some of the iDCM cases. [Corrected]

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          Author and article information

          Journal
          J. Am. Coll. Cardiol.
          Journal of the American College of Cardiology
          1558-3597
          0735-1097
          Mar 31 2015
          : 65
          : 12
          Affiliations
          [1 ] Cardiovascular Institute, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
          [2 ] Cardiovascular Institute, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Division of Cardiology, Sapienza University, Rome, Italy.
          [3 ] Division of Cardiology, Sapienza University, Rome, Italy.
          [4 ] Divisions of Newborn Medicine and Genetics and Program in Genomics, Children's Hospital, Boston, Massachusetts.
          [5 ] Heart Center, Massachusetts General Hospital, Boston, Massachusetts.
          [6 ] Cardiovascular Surgery, Massachusetts General Hospital, Boston, Massachusetts.
          [7 ] National Heart Lung Blood Institute Proteomics Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.
          [8 ] Heart and Vascular Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
          [9 ] Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado.
          [10 ] Cardiovascular Institute, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Heart Center, Massachusetts General Hospital, Boston, Massachusetts. Electronic address: fdelmont@bidmc.harvard.edu.
          Article
          S0735-1097(15)00290-9 NIHMS665976
          10.1016/j.jacc.2015.01.031
          25814227
          Copyright © 2015 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

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