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      Autonomic Nervous Dysfunction in Patients on Long-Term Hemodialysis

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          Abstract

          The level of plasma dopamine-beta-hydroxylase (DBH) activity in subjects at rest was found to be significantly lower in 12 patients on long-term hemodialysis than in a healthy 8-member control group: 28.3 ± 7.2 and 13.6 ± 7.6 IU/l, respectively (p < 0.01). Following immersion of one hand of each subject into cold water (4°C) for 1 min, a significant rise was observed in both groups, 6.1 ± 4.8 IU/l for the control and 1.6 ± 1.4 IU/l for the patient group (p < 0.01). Upon tilting up the head of all subjects, activity in both groups increased significantly, but a markedly smaller rise was found in the patient group: 5.8 ± 4.8 and 1.1 ± 1.6 IU/l for the two groups, respectively (p < 0.01). The data suggest an autonomic nervous dysfunction in patients on long-term hemodialysis.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1979
          1979
          02 December 2008
          : 23
          : 1
          : 10-13
          Affiliations
          Shinrakuen Hospital, Kidney Center, and 1st Department of Internal Medicine, Niigata University School of Medicine, Niigata
          Article
          181599 Nephron 1979;23:10–13
          10.1159/000181599
          109781
          © 1979 S. Karger AG, Basel

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          Page count
          Pages: 4
          Categories
          Original Paper

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