Autonomic Nervous Dysfunction in Patients on Long-Term Hemodialysis

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Abstract

The level of plasma dopamine-beta-hydroxylase (DBH) activity in subjects at rest was found to be significantly lower in 12 patients on long-term hemodialysis than in a healthy 8-member control group: 28.3 ± 7.2 and 13.6 ± 7.6 IU/l, respectively (p < 0.01). Following immersion of one hand of each subject into cold water (4°C) for 1 min, a significant rise was observed in both groups, 6.1 ± 4.8 IU/l for the control and 1.6 ± 1.4 IU/l for the patient group (p < 0.01). Upon tilting up the head of all subjects, activity in both groups increased significantly, but a markedly smaller rise was found in the patient group: 5.8 ± 4.8 and 1.1 ± 1.6 IU/l for the two groups, respectively (p < 0.01). The data suggest an autonomic nervous dysfunction in patients on long-term hemodialysis.

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Author and article information

Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1979

Publication date (Print): 1979

Publication date (Electronic): 02 December 2008

Volume: 23

Issue: 1

Pages: 10-13

Affiliations

Shinrakuen Hospital, Kidney Center, and 1st Department of Internal Medicine, Niigata University School of Medicine, Niigata

Article

Publisher ID: 181599 Other ID: Nephron 1979;23:10–13

DOI: 10.1159/000181599

PubMed ID: 109781

SO-VID: 861b4cc2-c323-4c50-af68-0df6916d6a4e

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 16 January 1978

Date accepted : 18 May 1978

Page count

Pages: 4

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