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      Tubulin-targeting agent combination therapies: dosing schedule could matter.

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      British journal of pharmacology
      Wiley

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          Abstract

          Tubulin-binding agents are potent cytotoxic drugs that are largely used to treat haematological malignancies and solid tumours. In this issue of British Journal of Pharmacology, doxorubicin was shown to decrease the activity of vincristine when administered simultaneously, unless cell cycle arrest mechanisms were disrupted. This observation emphasizes the need to better explore schedule-dependent antagonist effects in anticancer drug combination therapies.

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          Author and article information

          Journal
          Br. J. Pharmacol.
          British journal of pharmacology
          Wiley
          1476-5381
          0007-1188
          Apr 2013
          : 168
          : 7
          Affiliations
          [1 ] Institut Gustave Roussy, Villejuif cedex, France. eric.solary@igr.fr
          Article
          10.1111/bph.12101
          3605865
          23316995
          862b471a-00f1-43c1-a8ae-5469e598c276
          History

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