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Sprouting of CGRP nerve fibers in response to dentin injury in rat molars
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Abstract
Light and electron microscopic immunocytochemistry showed extensive increases in the
number of calcitonin gene-related peptide immunoreactive (CGRP-IR) nerve fibers subjacent
to injured root dentin of rat molars. Sprouting was greatest at 4 days and returned
to normal 10-21 days post injury. Non-CGRP-IR fibers were also increased at 4 days.
The results suggest that rapid reversible sprouting of sensory nerve fibers may be
an integral part of tissue reactions to injury.