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      A physiologically based mathematical model of integrated calcium homeostasis and bone remodeling

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      Bone
      Elsevier BV

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          Abstract

          Bone biology is physiologically complex and intimately linked to calcium homeostasis. The literature provides a wealth of qualitative and/or quantitative descriptions of cellular mechanisms, bone dynamics, associated organ dynamics, related disease sequela, and results of therapeutic interventions. We present a physiologically based mathematical model of integrated calcium homeostasis and bone biology constructed from literature data. The model includes relevant cellular aspects with major controlling mechanisms for bone remodeling and calcium homeostasis and appropriately describes a broad range of clinical and therapeutic conditions. These include changes in plasma parathyroid hormone (PTH), calcitriol, calcium and phosphate (PO4), and bone-remodeling markers as manifested by hypoparathyroidism and hyperparathyroidism, renal insufficiency, daily PTH 1-34 administration, and receptor activator of NF-kappaB ligand (RANKL) inhibition. This model highlights the utility of systems approaches to physiologic modeling in the bone field. The presented bone and calcium homeostasis model provides an integrated mathematical construct to conduct hypothesis testing of influential system aspects, to visualize elements of this complex endocrine system, and to continue to build upon iteratively with the results of ongoing scientific research. Copyright (c) 2009 Elsevier Inc. All rights reserved.

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          Author and article information

          Journal
          Bone
          Bone
          Elsevier BV
          87563282
          January 2010
          January 2010
          : 46
          : 1
          : 49-63
          Article
          10.1016/j.bone.2009.08.053
          19732857
          864ae7ef-d0a2-48a4-80ca-5d278fd0d945
          © 2010

          https://www.elsevier.com/tdm/userlicense/1.0/

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