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      Preventing Obstructions of Nanosized Drug Delivery Systems by the Extracellular Matrix

      1 , 1
      Advanced Healthcare Materials
      Wiley

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          Most cited references112

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          Hydrogels in Biology and Medicine: From Molecular Principles to Bionanotechnology

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            Single-particle tracking: applications to membrane dynamics.

            Measurements of trajectories of individual proteins or lipids in the plasma membrane of cells show a variety of types of motion. Brownian motion is observed, but many of the particles undergo non-Brownian motion, including directed motion, confined motion, and anomalous diffusion. The variety of motion leads to significant effects on the kinetics of reactions among membrane-bound species and requires a revision of existing views of membrane structure and dynamics.
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              Basement membranes: structure, assembly and role in tumour angiogenesis.

              In recent years, the basement membrane (BM)--a specialized form of extracellular matrix (ECM)--has been recognized as an important regulator of cell behaviour, rather than just a structural feature of tissues. The BM mediates tissue compartmentalization and sends signals to epithelial cells about the external microenvironment. The BM is also an important structural and functional component of blood vessels, constituting an extracellular microenvironment sensor for endothelial cells and pericytes. Vascular BM components have recently been found to be involved in the regulation of tumour angiogenesis, making them attractive candidate targets for potential cancer therapies.
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                Author and article information

                Journal
                Advanced Healthcare Materials
                Adv. Healthcare Mater.
                Wiley
                21922640
                February 2018
                February 2018
                November 09 2017
                : 7
                : 3
                : 1700739
                Affiliations
                [1 ]Department of Pharmaceutical Technology; University of Regensburg; Universitaetsstrasse 31 93040 Regensburg Germany
                Article
                10.1002/adhm.201700739
                865592c3-3210-4a10-84b1-7a93a25574d6
                © 2017

                http://doi.wiley.com/10.1002/tdm_license_1.1

                http://onlinelibrary.wiley.com/termsAndConditions#vor

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