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      Improvement of Left Ventricular Function in Chronic Alcoholics following Abstinence from Ethanol

      a , b , a

      Cardiology

      S. Karger AG

      Cardiomyopathy, alcoholic, Echocardiogram, Alcohol abuse

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          Abstract

          Preclinical abnormalities of left ventricular function are frequently found in chronic alcoholics. In 12 chronic alcoholics without cardiomyopathy and in 12 healthy controls, systolic time intervals and echocardiograms were investigated before and after 12 months of abstinence from alcohol. In chronic alcoholics, an increase was found in the PEP/LVET ratio (0.31 ± 0.06; in controls 0.24 ± 0.05; t = 3.11; p < 0.005), the diastolic interventricular septal thickness (6.0 ± 2.0 mm/m<sup>2</sup>; in controls 4.1 ± 1.0; t = 2.95; p < 0.01), the left ventricular wall thickness (6.3 ± 1.0 mm/m<sup>2</sup>; in controls 4.9 ± 1.0; t = 3.43; p < 0.005) and the left ventricular diastolic dimension (29 ± 4 mm/m<sup>2</sup>; in controls 26 ± 3; t = 2.08;p < 0.05). The left ventricular mass (135 ± 33 g/m<sup>2</sup>; in controls 113 ± 40; t= 1.47) did not differ from the controls. After 12 months of abstinence a significant decrease was found in the PEP/LVET ratio (0.26 ± 0.05, i.e. -16%; t = 3.59; p < 0.005), the diastolic interventricular septal thickness (4.7 ± 0.9 mm/m<sup>2</sup>, i.e. -22%; t = 2.73; p < 0.02), the left ventricular posterior wall thickness (5.6 ± 1.0 mm/m<sup>2</sup>, i.e. -11 %; t = 4.08; p < 0.001) and the left ventricular mass (109 ± 24 g/m<sup>2</sup>, i.e. -21 %; t = 6.53; p < 0.001). The left ventricular diastolic dimension (27 ± 2 mm/m<sup>2</sup>, i.e. -7%; t = 1.3) did not change. In conclusion, in chronic alcoholics, the abstinence from alcohol can be followed by an improvement of left ventricular function.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1989
          1989
          12 November 2008
          : 76
          : 4
          : 299-304
          Affiliations
          aUnità di Cure Intensive Cardiologiche, Servizio di Cardiologia, e bDivisione Medica I, Ospedale Civile, San Donà di Piave, Italy
          Article
          174507 Cardiology 1989;76:299–304
          10.1159/000174507
          2805017
          © 1989 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Categories
          Original Paper

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