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      [Pharmaokinetics of beta-escin after administration of various Aesculus extract containing formulations].

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      Die Pharmazie

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          Abstract

          With a specific radioimmunoassay the pharmacokinetics and relative bioavailability of escin was measured after administration of different formulations containing Aesculus-extract. Of special interest was the relative bioavailability of escin after administration of a newly developed film-coated tablet with sustained release in comparison to a reference formulation. In a cross-over steady-state study in 24 volunteers bioequivalence of test and reference preparation could be demonstrated. The 90% confidence interval of the AUC (O-tau) was 98.3 to 120.9%.

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          Author and article information

          Journal
          Pharmazie
          Die Pharmazie
          0031-7144
          0031-7144
          Aug 1996
          : 51
          : 8
          Affiliations
          [1 ] Dr. Willmar Schwabe Arzneimittel, Karlsruhe, Germany.
          Article
          8975251

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